| Career - Games | |||
| Rk | Player Name | Totals | |
| 1 | Koji Uehara | 436 | |
| 2 | Mike Mussina | 316 | |
| 3 | Mychal Givens | 290 | |
| 4 | Wandy Peralta | 276 | |
| 5 | Jeff Shaw | 275 | |
| 6 | Felix Rodriguez | 250 | |
| 7 | Trevor Hoffman | 245 | |
| 8 | Jason Isringhausen | 244 | |
| 9 | Tom Glavine | 233 | |
| 10 | Justin Duchscherer | 205 | |
| 11 | Andy Pettitte | 192 | |
| 12 | Todd Worrell | 189 | |
| 13 | Santiago Casilla | 179 | |
| 14 | Ken Dayley | 177 | |
| 15 | Javier Lopez | 177 | |
| 16 | Barry Zito | 172 | |
| 17 | Dwight Gooden | 170 | |
| 18 | Bruce Hurst | 156 | |
| 19 | Billy Wagner | 148 | |
| 20 | Jason Foley | 147 | |
| 21 | Sergio Romo | 145 | |
| 22 | Jarlin Garcia | 145 | |
| 23 | David Wells | 143 | |
| 24 | Yonny Chirinos | 141 | |
| 25 | Jeff Brantley | 136 | |
| Single Season - Games | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Jay Powell | 100 | 1999 | ||
| 2 | Ken Dayley | 91 | 1991 | ||
| 3 | Justin Duchscherer | 91 | 2006 | ||
| 4 | Yonny Chirinos | 88 | 2019 | ||
| 5 | Ken Dayley | 86 | 1990 | ||
| 6 | Jeff Brantley | 85 | 1991 | ||
| 7 | Dave Burba | 83 | 1995 | ||
| 8 | Shawn Camp | 83 | 2011 | ||
| 9 | Landen Roupp | 83 | 2025 | ||
| 10 | Blake Hawksworth | 81 | 2010 | ||
| 11 | Jason Bere | 79 | 1999 | ||
| 12 | Ben Joyce | 79 | 2025 | ||
| 13 | Todd Worrell | 77 | 1995 | ||
| 14 | Brian Flynn | 77 | 2017 | ||
| 15 | Wade LeBlanc | 77 | 2017 | ||
| 16 | Jeff Shaw | 76 | 1999 | ||
| 17 | Alex Claudio | 76 | 2018 | ||
| 18 | Daniel Bard | 76 | 2021 | ||
| 19 | Connor Overton | 76 | 2023 | ||
| 20 | Mychal Givens | 75 | 2018 | ||
| 21 | Jarlin Garcia | 75 | 2021 | ||
| 22 | Goose Gossage | 74 | 1995 | ||
| 23 | Michael Blazek | 74 | 2016 | ||
| 24 | Tom Edens | 73 | 1995 | ||
| 25 | Mychal Givens | 73 | 2019 | ||