| Career - Losses | |||
| Rk | Player Name | Totals | |
| 1 | Aaron Nola | 97 | |
| 2 | Luis Castillo | 76 | |
| 3 | Charlie Morton | 68 | |
| 4 | Eduardo Rodriguez | 36 | |
| 5 | Jordan Montgomery | 33 | |
| 6 | Kyle Hendricks | 27 | |
| 7 | Jarred Cosart | 26 | |
| 8 | Lance McCullers | 21 | |
| 9 | Adam Conley | 20 | |
| 10 | Huston Street | 18 | |
| 11 | J.A. Happ | 18 | |
| 12 | Yovani Gallardo | 17 | |
| 13 | Trevor Cahill | 15 | |
| 14 | Mitchell Parker | 15 | |
| 15 | Taj Bradley | 14 | |
| 16 | Adam Cimber | 13 | |
| 17 | Trent Thornton | 13 | |
| 18 | Deivi Garcia | 13 | |
| 19 | Jon Niese | 12 | |
| 20 | Brayan Bello | 12 | |
| 21 | Tyler Skaggs | 11 | |
| 22 | Dan Straily | 11 | |
| 23 | Noah Syndergaard | 11 | |
| 24 | Sean Doolittle | 10 | |
| 25 | Ivan Nova | 10 | |
| Single Season - Losses | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Kyle Hendricks | 16 | 2016 | ||
| 2 | Jordan Montgomery | 16 | 2023 | ||
| 3 | Trevor Cahill | 15 | 2014 | ||
| 4 | Mitchell Parker | 15 | 2025 | ||
| 5 | Adam Conley | 14 | 2016 | ||
| 6 | Charlie Morton | 14 | 2019 | ||
| 7 | Aaron Nola | 14 | 2023 | ||
| 8 | Taj Bradley | 14 | 2025 | ||
| 9 | Jarred Cosart | 13 | 2014 | ||
| 10 | Luis Castillo | 13 | 2018 | ||
| 11 | Trent Thornton | 13 | 2020 | ||
| 12 | Deivi Garcia | 13 | 2021 | ||
| 13 | Luis Castillo | 12 | 2025 | ||
| 14 | Aaron Nola | 12 | 2025 | ||
| 15 | Yovani Gallardo | 11 | 2014 | ||
| 16 | Dan Straily | 11 | 2014 | ||
| 17 | Huston Street | 11 | 2014 | ||
| 18 | Jarred Cosart | 11 | 2015 | ||
| 19 | Aaron Nola | 11 | 2016 | ||
| 20 | Aaron Nola | 11 | 2020 | ||
| 21 | Lance McCullers | 11 | 2021 | ||
| 22 | Noah Syndergaard | 11 | 2023 | ||
| 23 | Luis Castillo | 11 | 2024 | ||
| 24 | Aaron Nola | 11 | 2024 | ||
| 25 | J.A. Happ | 10 | 2016 | ||